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Scenarios for autoimmunization of T and B cells in myasthenia gravis.

Abstract:

We have studied responses in thymoma patients to interferon-alpha and to the acetylcholine receptor (AChR) in early-onset myasthenia gravis (EOMG), seeking clues to autoimmunizing mechanisms. Our new evidence implicates a two-step process: (step 1) professional antigen-presenting cells and thymic epithelial cells prime AChR-specific T cells; then (step 2) thymic myoid cells subsequently provoke germinal center formation in EOMG. Our unifying hypothesis proposes that AChR epitopes expressed by...

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Publication status:
Published

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Publisher copy:
10.1196/annals.1254.026

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Journal:
Annals of the New York Academy of Sciences More from this journal
Volume:
998
Issue:
1
Pages:
237-256
Publication date:
2003-09-01
DOI:
EISSN:
1749-6632
ISSN:
0077-8923

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