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GOAT--a simple LC-MS/MS gradient optimization tool.

Abstract:

Modern nano-HPLC systems are capable of extremely precise control of solvent gradients, allowing high-resolution separation of peptides. Most proteomics laboratories use a simple linear analytical gradient for nano-LC-MS/MS experiments, though recent evidence indicates that optimized non-linear gradients result in increased peptide and protein identifications from cell lysates. In concurrent work, we examined non-linear gradients for the analysis of samples fractionated at the peptide level, ...

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Publication status:
Published

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Publisher copy:
10.1002/pmic.201300524
Publisher:
Wiley
Journal:
Proteomics More from this journal
Volume:
14
Issue:
12
Pages:
1467-1471
Publication date:
2014-06-01
DOI:
EISSN:
1615-9861
ISSN:
1615-9853
Language:
English
Keywords:
Pubs id:
pubs:459607
UUID:
uuid:1cbfef60-9345-4b2a-ae9a-d4ab17aeebbf
Local pid:
pubs:459607
Source identifiers:
459607
Deposit date:
2014-05-28

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