Targeting tumour hypoxia in breast cancer.

Journal article

Breast cancer is the most common malignancy in women. Hypoxia occurs in breast cancer and in other solid tumours due to the tumour outgrowing the existing vasculature. Hypoxia leads to an adaptive response, orchestrated by HIF-1 (hypoxia-inducible factor-1), that is crucial for tumour progression and therapy resistance responsible for poor patient outcome. In several studies, downstream targets of HIF-1alpha were considered as hypoxia markers. The biological heterogeneity of breast cancer has...

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Authors: Milani, M; Harris, A

• Publication status: Published
• Journal: European journal of cancer (Oxford, England : 1990)
• Volume: 44
• Issue: 18
• Pages: 2766-2773
• Publication date: 2008-12-01
• DOI: 10.1016/j.ejca.2008.09.025
• EISSN: 1879-0852
• ISSN: 0959-8049
• Language: English
• Keywords: Female; Hypoxia-Inducible Factor 1, alpha Subunit; Breast Neoplasms; Treatment Outcome; Humans; Anoxia; Tumor Markers, Biological; Gene Expression Profiling; Prognosis