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Functional conservation of HTLV-1 Rex balances the immune pressure for sequence variation in the Rex gene

Abstract:

Naturally occurring mutations in Human T-cell Leukemia Virus Type 1 (HTLV-1) Tax protein lead to loss of recognition by cytotoxic T-lymphocytes. Most of these mutations also abolish or severely impair the transactivation function of Tax. Ninety percent of the Rex gene, which encodes the viral regulator of mRNA splicing (Rex), overlaps with theTax gene. In this paper, we report that four previously described point mutations in Tax that abolished CTL recognition and a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Institution:
University of Oxford
Department:
Medical Sciences Division - Nuffield Department of Clinical Medicine - NDM John Radcliffe
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Institution:
Institut für Virologie and Immunbiologie
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Institution:
University of Oxford
Department:
Medical Sciences Division - Nuffield Department of Clinical Medicine - NDM John Radcliffe
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Institution:
Imperial College School of Medicine, St. Mary's Hospital
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Institution:
University of Oxford
Department:
Medical Sciences Division - Nuffield Department of Clinical Medicine - NDM John Radcliffe
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Funding agency for:
Richard E.T. Smith
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Funding agency for:
Sarah Booth
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Funding agency for:
Susan Daenke
Publisher:
Elsevier Publisher's website
Journal:
Virology Journal website
Volume:
237
Issue:
2
Pages:
397–403
Publication date:
1997-10-05
URN:
uuid:1cb4fdb3-e64e-4620-a99e-24d676b08067
Local pid:
ora:10727

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