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Journal article

Structural insights into the mechanisms of agonism and antagonism in oestrogen receptor isoforms.

Abstract:

Here we summarise the results that have emerged from our structural studies on the oestrogen receptor (ER) ligand-binding domain. We have investigated the conformational effects of a variety of ligands on the structures of both ER isoforms. Each class of ligand (agonists, partial agonists and selective oestrogen receptor modulators) induces a unique conformation in the receptor's ligand-dependent transcriptional activation function. Together these studies have broadened our understanding of E...

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Publication status:
Published

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Journal:
European journal of cancer (Oxford, England : 1990)
Volume:
36 Suppl 4
Issue:
SUPPL. 4
Pages:
S17-S18
Publication date:
2000-09-01
DOI:
EISSN:
1879-0852
ISSN:
0959-8049
Source identifiers:
317559
Language:
English
Keywords:
Pubs id:
pubs:317559
UUID:
uuid:1cae65bd-721e-48ed-9d5a-0b5c1836e430
Local pid:
pubs:317559
Deposit date:
2012-12-19

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