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Thesis

Neuroanatomical screening and analysis of transgenic and ENU induced mutagenised mice

Abstract:

I have sought to discover genetic causes of neuroanatomical defects by conducting N-ethyl-N-nitrosourea mutagenesis and transgenic knock out screens in mice. The rationale behind this is that mutations causal to structural defects will be informative about developmental neurobiology and the biological basis of behaviour. Direct screening for behavioural abnormalities in mice has historically been arduous and yielded few findings due to small effect sizes and limited statistical power. My a...

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Institution:
University of Oxford
Research group:
Flint
Oxford college:
Corpus Christi College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Human Genetics,Wellcome Trust Centre for Human Genetics
Role:
Author

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Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:1ca62d53-e801-49be-959b-99f7092ad9fb
Local pid:
ora:12071

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