- Abstract:
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I have sought to discover genetic causes of neuroanatomical defects by conducting N-ethyl-N-nitrosourea mutagenesis and transgenic knock out screens in mice. The rationale behind this is that mutations causal to structural defects will be informative about developmental neurobiology and the biological basis of behaviour. Direct screening for behavioural abnormalities in mice has historically been arduous and yielded few findings due to small effect sizes and limited statistical power. My a...
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Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
- Funding agency for:
- Andrew Edwards
- Publication date:
- 2011
- Type of award:
- DPhil
- Level of award:
- Doctoral
- URN:
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uuid:1ca62d53-e801-49be-959b-99f7092ad9fb
- Local pid:
- ora:12071
- Copyright holder:
- Andrew Edwards
- Copyright date:
- 2012
- Notes:
- This thesis is not currently available via ORA.
Thesis
Neuroanatomical screening and analysis of transgenic and ENU induced mutagenised mice
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Funding
+ Le Fondation Jerome Lejeune; Wellcome Trust; Corpus Christi College
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