Thesis
Neuroanatomical screening and analysis of transgenic and ENU induced mutagenised mice
- Abstract:
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I have sought to discover genetic causes of neuroanatomical defects by conducting N-ethyl-N-nitrosourea mutagenesis and transgenic knock out screens in mice. The rationale behind this is that mutations causal to structural defects will be informative about developmental neurobiology and the biological basis of behaviour. Direct screening for behavioural abnormalities in mice has historically been arduous and yielded few findings due to small effect sizes and limited statistical power. My a...
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Funding
+ Le Fondation Jerome Lejeune; Wellcome Trust; Corpus Christi College
More from this funder
Funding agency for:
Edwards, A
Bibliographic Details
- Publication date:
- 2011
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:1ca62d53-e801-49be-959b-99f7092ad9fb
- Local pid:
- ora:12071
- Deposit date:
- 2015-08-03
Terms of use
- Copyright holder:
- Edwards, A
- Copyright date:
- 2012
- Notes:
- This thesis is not currently available via ORA.
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