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Distinct developmental profile of lower-body adipose tissue defines resistance against obesity-associated metabolic complications.

Abstract:

Upper- and lower-body fat depots exhibit opposing associations with obesity-related metabolic disease. We defined the relationship between DEXA-quantified fat depots and diabetes/cardiovascular risk factors in a healthy population-based cohort (n = 3,399). Gynoid fat mass correlated negatively with insulin resistance after total fat mass adjustment, whereas the opposite was seen for abdominal fat. Paired transcriptomic analysis of gluteal subcutaneous adipose tissue (GSAT) and abdominal subcu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.2337/db14-0385

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Institution:
University of Oxford
Department:
Oxford, MSD, OCDEM
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Department of Surgical Sciences
Role:
Author
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Wellcome Trust More from this funder
National Institute for Health Research Biomedical Research Centre Programme, Oxford More from this funder
Publisher:
American Diabetes Association Publisher's website
Journal:
Diabetes Journal website
Volume:
63
Issue:
11
Pages:
3785-3797
Publication date:
2014-11-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:1ca32c0f-a79c-4e4f-9c49-faa9c1c2f31d
Source identifiers:
471008
Local pid:
pubs:471008

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