Upper- and lower-body fat depots exhibit opposing associations with obesity-related metabolic disease. We defined the relationship between DEXA-quantified fat depots and diabetes/cardiovascular risk factors in a healthy population-based cohort (n = 3,399). Gynoid fat mass correlated negatively with insulin resistance after total fat mass adjustment, whereas the opposite was seen for abdominal fat. Paired transcriptomic analysis of gluteal subcutaneous adipose tissue (GSAT) and abdominal subcu...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
- Copyright holder:
- American Diabetes Association
- Copyright date:
- © 2014 by the American Diabetes Association.
Distinct developmental profile of lower-body adipose tissue defines resistance against obesity-associated metabolic complications.
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