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Activation of human mucosal-associated invariant T cells induces CD40L-dependent maturation of monocyte-derived and primary dendritic cells

Abstract:

Mucosal-associated invariant T (MAIT) cells are innate T cells that recognize intermediates of the vitamin B2 biosynthetic pathway presented by the monomorphic MR1 molecule. It remains unclear whether, in addition to their cytolytic activity that is important in antimicrobial defense, MAIT cells have immune-modulatory functions that could enhance dendritic cell (DC) maturation. In this study, we investigated the molecular mechanisms dictating the interactions between human MAIT cells and DCs ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.4049/jimmunol.1700615

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
ORCID:
0000-0002-4821-3801
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
More by this author
Role:
Author
ORCID:
0000-0003-4182-4236
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More from this funder
Funding agency for:
Cerundolo, V
Grant:
C399/A2291
Medical Research Council More from this funder
Publisher:
American Association of Immunologists Publisher's website
Journal:
Journal of Immunology Journal website
Volume:
199
Issue:
8
Pages:
2631-2638
Publication date:
2018-09-06
Acceptance date:
2017-08-10
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Pmid:
28877992
Source identifiers:
729983

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