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Comparison of the effects of sub-hypnotic concentrations of propofol and halothane on the acute ventilatory response to hypoxia.

Abstract:

To compare the effects of sub-anaesthetic concentrations of propofol and halothane on the respiratory control system, we have studied the acute ventilatory response to isocapnic hypoxia (AHVR) in 12 adults with and without three different concentrations of propofol and halothane. Target doses for propofol were 0, 0.05, 0.1 and 0.2 of the effective plasma concentration (EC50 = 8.1 micrograms ml-1). Target doses for halothane were 0, 0.05, 0.1 and 0.2 minimum alveolar concentration (MAC = 0.77%...

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Publication status:
Published

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Publisher copy:
10.1093/bja/75.6.713

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
British journal of anaesthesia More from this journal
Volume:
75
Issue:
6
Pages:
713-718
Publication date:
1995-12-01
DOI:
EISSN:
1471-6771
ISSN:
0007-0912
Language:
English
Keywords:
Pubs id:
pubs:113802
UUID:
uuid:1c9ba9f5-d6fa-4bbd-a2a4-b793a999dc5d
Local pid:
pubs:113802
Source identifiers:
113802
Deposit date:
2013-11-17

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