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Integrating genealogy and epidemiology: the ancestral infection and selection graph as a model for reconstructing host virus histories.

Abstract:

We model the genealogies of coupled haploid host-virus populations. Hosts reproduce and replace other hosts as in the Moran model. The virus can be transmitted between individuals of the same and succeeding generations. The epidemic model allows a selective advantage for susceptible over infected hosts. The coupled host-virus ancestry of a sample of hosts is embedded in a branching and coalescing structure that we call the Ancestral Infection and Selection Graph, a direct analogue to the Ance...

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Publication status:
Published

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Publisher copy:
10.1016/j.tpb.2005.03.003
Journal:
Theoretical population biology More from this journal
Volume:
68
Issue:
1
Pages:
65-75
Publication date:
2005-07-01
DOI:
EISSN:
1096-0325
ISSN:
0040-5809
Language:
English
Keywords:
Pubs id:
pubs:103451
UUID:
uuid:1c97c125-2547-42d7-b2d1-c9c449836a48
Local pid:
pubs:103451
Source identifiers:
103451
Deposit date:
2012-12-19

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