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Genetic variation in the serotonin pathway and smoking cessation with nicotine replacement therapy: new data from the Patch in Practice trial and pooled analyses.

Abstract:

The serotonin pathway has been implicated in nicotine dependence and may influence smoking cessation. Therefore, 792 cigarette smokers from the Patch in Practice trial were genotyped for the tryptophan hydroxylase (TPH1 A779C), serotonin transporter (SLC6A45-HTTLPR), and 5-HT1A (HTR1A C-1019G) polymorphisms. Cox regression analysis did not demonstrate significant effects of any of the three genotypes on relapse to smoking: TPH1 (Reference AA; AC: hazard ratio (HR) 0.99, 95% confidence interva...

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Institution:
University of Oxford
Department:
Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences
Role:
Author
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Journal:
Drug and alcohol dependence
Volume:
98
Issue:
1-2
Pages:
77-85
Publication date:
2008-11-05
DOI:
EISSN:
1879-0046
ISSN:
0376-8716
URN:
uuid:1c91afba-0586-4723-9513-f72f3b997ac9
Source identifiers:
191189
Local pid:
pubs:191189

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