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Journal article

The structure and transcriptional analysis of a global regulator from Neisseria meningitidis.

Abstract:

Neisseria meningitidis, a causative agent of bacterial meningitis, has a relatively small repertoire of transcription factors, including NMB0573 (annotated AsnC), a member of the Lrp-AsnC family of regulators that are widely expressed in both Bacteria and Archaea. In the present study we show that NMB0573 binds to l-leucine and l-methionine and have solved the structure of the protein with and without bound amino acids. This has shown, for the first time that amino acid binding does not induc...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m701082200

Authors


Sainsbury, S More by this author
Capper, RG More by this author
Jordan, PW More by this author
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Journal:
The Journal of biological chemistry
Volume:
282
Issue:
19
Pages:
14655-14664
Publication date:
2007-05-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:1c919713-a66c-4213-9765-0a336db89995
Source identifiers:
20340
Local pid:
pubs:20340

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