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Mitochondrial tumour suppressors: a genetic and biochemical update.

Abstract:

Since the discovery 5 years ago that the D-subunit of succinate dehydrogenase (SDHD) can behave as a classic tumour suppressor, other nuclear-encoded mitochondrial proteins (SDHB, SDHC and fumarate hydratase) have been implicated in tumour susceptibility. Mutations in these proteins are principally involved in familial predisposition to benign tumours, but the spectrum of inherited lesions is increasingly recognized to include malignant tumours, such as malignant phaeochromocytomas and renal ...

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Publisher copy:
10.1038/nrc1737

Authors


Gottlieb, E More by this author
Tomlinson, IP More by this author
Journal:
Nature reviews. Cancer
Volume:
5
Issue:
11
Pages:
857-866
Publication date:
2005-11-05
DOI:
EISSN:
1474-1768
ISSN:
1474-175X
URN:
uuid:1c8848a0-68a8-4764-bfb9-e3ca16c2d773
Source identifiers:
72247
Local pid:
pubs:72247

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