Journal article
Mitochondrial tumour suppressors: a genetic and biochemical update.
- Abstract:
-
Since the discovery 5 years ago that the D-subunit of succinate dehydrogenase (SDHD) can behave as a classic tumour suppressor, other nuclear-encoded mitochondrial proteins (SDHB, SDHC and fumarate hydratase) have been implicated in tumour susceptibility. Mutations in these proteins are principally involved in familial predisposition to benign tumours, but the spectrum of inherited lesions is increasingly recognized to include malignant tumours, such as malignant phaeochromocytomas and renal ...
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- Publisher copy:
- 10.1038/nrc1737
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Bibliographic Details
- Journal:
- Nature reviews. Cancer
- Volume:
- 5
- Issue:
- 11
- Pages:
- 857-866
- Publication date:
- 2005-11-05
- DOI:
- EISSN:
-
1474-1768
- ISSN:
-
1474-175X
- URN:
-
uuid:1c8848a0-68a8-4764-bfb9-e3ca16c2d773
- Source identifiers:
-
72247
- Local pid:
- pubs:72247
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2005
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