- Abstract:
-
Since the discovery 5 years ago that the D-subunit of succinate dehydrogenase (SDHD) can behave as a classic tumour suppressor, other nuclear-encoded mitochondrial proteins (SDHB, SDHC and fumarate hydratase) have been implicated in tumour susceptibility. Mutations in these proteins are principally involved in familial predisposition to benign tumours, but the spectrum of inherited lesions is increasingly recognized to include malignant tumours, such as malignant phaeochromocytomas and renal ...
Expand abstract - Publisher copy:
- 10.1038/nrc1737
-
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- Journal:
- Nature reviews. Cancer
- Volume:
- 5
- Issue:
- 11
- Pages:
- 857-866
- Publication date:
- 2005-11-05
- DOI:
- EISSN:
-
1474-1768
- ISSN:
-
1474-175X
- URN:
-
uuid:1c8848a0-68a8-4764-bfb9-e3ca16c2d773
- Source identifiers:
-
72247
- Local pid:
- pubs:72247
- Language:
- English
- Keywords:
- Copyright date:
- 2005
Journal article
Mitochondrial tumour suppressors: a genetic and biochemical update.
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