- Abstract:
-
The well-characterised association between HLA-B*27:05 and protection against HIV disease progression has been linked to immunodominant HLA-B*27:05-restricted CD8+ T-cell responses towards the conserved Gag 263-272 ('KK10') and Pol 901-909 'KY9' epitopes. We here studied the impact of the 3 amino acid differences between HLA-B*27:05 and the closely-related HLA-B*27:02 on the HIV-specific CD8+ T-cell response hierarchy and on immune control of HIV. Genetic epidemiological data indicate that bo...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.0mb)
-
- Publisher copy:
- 10.1128/jvi.01685-17
-
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- Publisher:
- American Society for Microbiology Publisher's website
- Journal:
- Journal of Virology Journal website
- Volume:
- 92
- Issue:
- 4
- Pages:
- e01685-17
- Publication date:
- 2017-11-05
- Acceptance date:
- 2017-11-22
- DOI:
- EISSN:
-
1098-5514
- ISSN:
-
0022-538X
- Pubs id:
-
pubs:803186
- URN:
-
uri:1c881e0d-a8f3-4de4-8b5b-ebca9a144eaf
- UUID:
-
uuid:1c881e0d-a8f3-4de4-8b5b-ebca9a144eaf
- Local pid:
- pubs:803186
- Language:
- English
- Keywords:
- Copyright holder:
- Adland et al
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 Adland et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Journal article
Differential immunodominance hierarchy of CD8+ T cell responses in HLA-B*27:05 and B*27:02-mediated control of HIV-1 infection.
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Frederick National Laboratory for Cancer Research
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University of California San Francisco
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Gladstone Institute of Virology and Immunology
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