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Differential immunodominance hierarchy of CD8+ T cell responses in HLA-B*27:05 and B*27:02-mediated control of HIV-1 infection.

Abstract:

The well-characterised association between HLA-B*27:05 and protection against HIV disease progression has been linked to immunodominant HLA-B*27:05-restricted CD8+ T-cell responses towards the conserved Gag 263-272 ('KK10') and Pol 901-909 'KY9' epitopes. We here studied the impact of the 3 amino acid differences between HLA-B*27:05 and the closely-related HLA-B*27:02 on the HIV-specific CD8+ T-cell response hierarchy and on immune control of HIV. Genetic epidemiological data indicate that bo...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/jvi.01685-17

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Lavandier, N More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
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Frederick National Laboratory for Cancer Research More from this funder
University of California San Francisco More from this funder
Gladstone Institute of Virology and Immunology More from this funder
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Publisher:
American Society for Microbiology Publisher's website
Journal:
Journal of Virology Journal website
Volume:
92
Issue:
4
Pages:
e01685-17
Publication date:
2017-11-05
Acceptance date:
2017-11-22
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Pubs id:
pubs:803186
URN:
uri:1c881e0d-a8f3-4de4-8b5b-ebca9a144eaf
UUID:
uuid:1c881e0d-a8f3-4de4-8b5b-ebca9a144eaf
Local pid:
pubs:803186
Language:
English
Keywords:

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