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Journal article

Kinetics of abacavir-induced remodelling of the major histocompatibility complex class I peptide repertoire

Abstract:

Abacavir hypersensitivity syndrome can occur in individuals expressing the HLA-B*57:01 major histocompatibility complex class I allotype when utilising the drug abacavir as a part of their anti-retroviral regimen. The drug is known to bind within the HLA-B*57:01 antigen binding cleft, leading to the selection of novel self-peptide ligands, thus provoking life-threatening immune responses. However, the sub-cellular location of abacavir binding and the mechanics of altered peptide selection are...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fimmu.2021.672737

Authors


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Biotechnology and Biological Sciences Research Council More from this funder
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
12
Article number:
672737
Publication date:
2021-05-19
Acceptance date:
2021-04-26
DOI:
EISSN:
1664-3224
Pmid:
34093574
Language:
English
Keywords:
Pubs id:
1181940
Local pid:
pubs:1181940
Deposit date:
2021-06-27

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