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Journal article

Covalent strategies for targeting messenger and non-coding RNAs: an updated review on siRNA, miRNA and antimiR conjugates

Abstract:

Oligonucleotide-based therapy has become an alternative to classical approaches in the search of novel therapeutics involving gene-related diseases. Several mechanisms have been described in which demonstrate the pivotal role of oligonucleotide for modulating gene expression. Antisense oligonucleotides (ASOs) and more recently siRNAs and miRNAs have made important contributions either in reducing aberrant protein levels by sequence-specific targeting messenger RNAs (mRNAs) or restoring the an...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3390/genes9020074

Authors


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Role:
Author
ORCID:
0000-0002-8405-4844
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0001-6421-7733
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Role:
Author
ORCID:
0000-0002-9415-7337
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Role:
Author
ORCID:
0000-0001-5383-9334
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Grant:
CTQ2014-52588-R, CTQ2017-84415-R, RTC-2014-2038-1
Publisher:
MDPI Publisher's website
Journal:
Genes Journal website
Volume:
9
Issue:
2
Pages:
Article: 74
Publication date:
2018-02-06
Acceptance date:
2018-01-26
DOI:
ISSN:
2073-4425
Pubs id:
pubs:825410
URN:
uri:1c8801fe-aee5-4f47-8c32-ca8db50fbd1c
UUID:
uuid:1c8801fe-aee5-4f47-8c32-ca8db50fbd1c
Local pid:
pubs:825410

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