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Journal article

Covalent strategies for targeting messenger and non-coding RNAs: an updated review on siRNA, miRNA and antimiR conjugates

Abstract:

Oligonucleotide-based therapy has become an alternative to classical approaches in the search of novel therapeutics involving gene-related diseases. Several mechanisms have been described in which demonstrate the pivotal role of oligonucleotide for modulating gene expression. Antisense oligonucleotides (ASOs) and more recently siRNAs and miRNAs have made important contributions either in reducing aberrant protein levels by sequence-specific targeting messenger RNAs (mRNAs) or restoring the an...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.3390/genes9020074

Authors


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Role:
Author
ORCID:
0000-0002-8405-4844
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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0001-6421-7733
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Role:
Author
ORCID:
0000-0002-9415-7337
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Role:
Author
ORCID:
0000-0001-5383-9334
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Grant:
CTQ2014-52588-R, CTQ2017-84415-R, RTC-2014-2038-1
Publisher:
MDPI Publisher's website
Journal:
Genes Journal website
Volume:
9
Issue:
2
Article number:
74
Publication date:
2018-02-06
Acceptance date:
2018-01-26
DOI:
ISSN:
2073-4425
Pmid:
29415514
Source identifiers:
825410
Language:
English
Keywords:
Pubs id:
pubs:825410
UUID:
uuid:1c8801fe-aee5-4f47-8c32-ca8db50fbd1c
Local pid:
pubs:825410
Deposit date:
2018-06-07

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