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Journal article

Autophagy in the pathogenesis of myelodysplastic syndrome and acute myeloid leukemia.

Abstract:

Autophagy is a conserved cellular pathway responsible for the sequestration of spent organelles and protein aggregates from the cytoplasm and their delivery into lysosomes for degradation. Autophagy plays an important role in adaptation to starvation, in cell survival, immunity, development and cancer. Recent evidence in mice suggests that autophagic defects in hematopoietic stem cells (HSCs) may be implicated in leukemia. Indeed, mice lacking Atg7 in HSCs develop an atypical myeloproliferati...

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Publication status:
Published

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Publisher copy:
10.4161/cc.10.11.15673

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Cell cycle (Georgetown, Tex.)
Volume:
10
Issue:
11
Pages:
1719-1725
Publication date:
2011-06-01
DOI:
EISSN:
1551-4005
ISSN:
1538-4101
Source identifiers:
134988
Language:
English
Keywords:
Pubs id:
pubs:134988
UUID:
uuid:1c6e279c-4fd5-4e4a-91c8-98bbd2afa2cf
Local pid:
pubs:134988
Deposit date:
2012-12-19

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