Hypoxia-inducible factor-1alpha and -2alpha are expressed in most rectal cancers but only hypoxia-inducible factor-1alpha is associated with prognosis.

Journal article

The hypoxia-mediated response of tumours is a major determining factor in growth and metastasis. Understanding tumour biology under hypoxic conditions is crucial for the development of antiangiogenic therapy. Using one of the largest cohorts of rectal adenocarcinomas to date, this study investigated hypoxia-inducible factor-1alpha (HIF-1alpha) and HIF-2alpha protein expression in relation to rectal cancer recurrence and cancer-specific survival. Patients (n=90) who had undergone surgery for r...

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Authors: Rasheed, S; Harris, A; Tekkis, P; Turley, H; Silver, A

• Publication status: Published
• Journal: British journal of cancer
• Volume: 100
• Issue: 10
• Pages: 1666-1673
• Publication date: 2009-05-01
• DOI: 10.1038/sj.bjc.6605026
• EISSN: 1532-1827
• ISSN: 0007-0920
• Language: English
• Keywords: Middle Aged; Hypoxia-Inducible Factor 1, alpha Subunit; Adult; Adenocarcinoma; Neoplasm Staging; Neovascularization, Pathologic; Basic Helix-Loop-Helix Transcription Factors; Humans; Rectal Neoplasms; Survival Analysis; Aged; Disease Progression; Female; Prognosis; Male