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Plasmodium falciparum histones induce endothelial proinflammatory response and barrier dysfunction.

Abstract:

Plasmodium falciparum is a protozoan parasite of human erythrocytes that causes the most severe form of malaria. Severe P. falciparum infection is associated with endothelial activation and permeability, which are important determinants of the outcome of the infection. How endothelial cells become activated is not fully understood, particularly with regard to the effects of parasite subcomponents. We demonstrated that P. falciparum histones extracted from merozoites (HeH) directly stimulated ...

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Publication status:
Published

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Journal:
American journal of pathology More from this journal
Volume:
180
Issue:
3
Pages:
1028-1039
Publication date:
2012-03-01
DOI:
EISSN:
1525-2191
ISSN:
0002-9440

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