Journal article
Synthetic partial agonists reveal key steps in IP3 receptor activation
- Abstract:
-
Inositol 1,4,5-trisphosphate receptors (IP3Rs) are ubiquitous intracellular Ca2+ channels. IP3 binding to the IP 3-binding core (IBC) near the N terminus initiates conformational changes that lead to opening of a pore. The mechanisms underlying this process are unresolved. We synthesized 2-O-modified IP3 analogs that are partial agonists of IP3R. These are similar to IP3 in their interactions with the IBC, but they are less effective than IP3 in rearranging the relationship between the IBC an...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Wellcome Trust
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Biotechnology and Biological Sciences Research Council
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Chemical Biology Journal website
- Volume:
- 5
- Pages:
- 631–639
- Publication date:
- 2009-09-01
- Acceptance date:
- 2009-05-28
- DOI:
- ISSN:
-
1552-4469 and 1552-4450
- Pmid:
-
19668195
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:640322
- UUID:
-
uuid:1c66249e-d9a0-4845-a7c8-8023c68fc516
- Local pid:
- pubs:640322
- Source identifiers:
-
640322
- Deposit date:
- 2016-08-24
Terms of use
- Copyright holder:
- Macmillan Publishers Limited
- Copyright date:
- 2009
- Notes:
-
This is an
accepted manuscript of a journal article published by Nature Publishing Group in Nature Chemical Biology on 2009-08-09, available online: http://dx.doi.org/10.1038/nchembio.195
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