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A high-content phenotypic screen reveals the disruptive potency of quinacrine and 3',4'-dichlorobenzamil on the digestive vacuole of Plasmodium falciparum.

Abstract:

Plasmodium falciparum is the etiological agent of malignant malaria and has been shown to exhibit features resembling programmed cell death. This is triggered upon treatment with low micromolar doses of chloroquine or other lysosomotrophic compounds and is associated with leakage of the digestive vacuole contents. In order to exploit this cell death pathway, we developed a high-content screening method to select compounds that can disrupt the parasite vacuole, as measured by the leakage of in...

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Publisher copy:
10.1128/aac.01441-13

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Preiser, PR More by this author
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Journal:
Antimicrobial agents and chemotherapy
Volume:
58
Issue:
1
Pages:
550-558
Publication date:
2014
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:1c620ebb-c0b8-4197-86e2-e2ac6eb52b48
Source identifiers:
438866
Local pid:
pubs:438866

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