Journal article
A high-content phenotypic screen reveals the disruptive potency of quinacrine and 3',4'-dichlorobenzamil on the digestive vacuole of Plasmodium falciparum.
- Abstract:
-
Plasmodium falciparum is the etiological agent of malignant malaria and has been shown to exhibit features resembling programmed cell death. This is triggered upon treatment with low micromolar doses of chloroquine or other lysosomotrophic compounds and is associated with leakage of the digestive vacuole contents. In order to exploit this cell death pathway, we developed a high-content screening method to select compounds that can disrupt the parasite vacuole, as measured by the leakage of in...
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- Publisher copy:
- 10.1128/aac.01441-13
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Bibliographic Details
- Journal:
- Antimicrobial agents and chemotherapy
- Volume:
- 58
- Issue:
- 1
- Pages:
- 550-558
- Publication date:
- 2014-01-01
- DOI:
- EISSN:
-
1098-6596
- ISSN:
-
0066-4804
- Source identifiers:
-
438866
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:438866
- UUID:
-
uuid:1c620ebb-c0b8-4197-86e2-e2ac6eb52b48
- Local pid:
- pubs:438866
- Deposit date:
- 2014-01-30
Terms of use
- Copyright date:
- 2014
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