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Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is a common adhesive phenotype and is associated with severe malaria.

Abstract:

Sequestration of malaria-infected erythrocytes in the peripheral circulation has been associated with the virulence of Plasmodium falciparum. Defining the adhesive phenotypes of infected erythrocytes may therefore help us to understand how severe disease is caused and how to prevent or treat it. We have previously shown that malaria-infected erythrocytes may form apparent autoagglutinates of infected erythrocytes. Here we show that such autoagglutination of a laboratory line of P. falciparum ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.98.4.1805

Authors


Ferguson, DJ More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
98
Issue:
4
Pages:
1805-1810
Publication date:
2001-02-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:1c582c4b-121f-490f-8272-48d6c296cb4f
Source identifiers:
31814
Local pid:
pubs:31814

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