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Synergistic effects of osteonectin and NGF in promoting survival and neurite outgrowth of superior cervical ganglion neurons.

Abstract:

Schwann cells (SCs) play a major role in the successful regeneration of peripheral nerves regeneration. Here we examined the effects of osteonectin (ON), a major factor secreted by SCs, on survival and neuritogenesis of mouse superior cervical ganglion (SCG) neurons. SC conditioned medium (SCCM) not only promoted the survival and neuritogenesis of SCG neurons at a level comparable to nerve growth factor (NGF) but also doubled the neurite length of NGF-treated SCG neurons. SCCM neuritogenic ef...

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Brain research More from this journal
Volume:
1289
Pages:
1-13
Publication date:
2009-09-01
DOI:
EISSN:
1872-6240
ISSN:
0006-8993
Language:
English
Keywords:
Pubs id:
pubs:95240
UUID:
uuid:1c57b407-dff2-4cd5-92b1-a5d78b748fe1
Local pid:
pubs:95240
Source identifiers:
95240
Deposit date:
2012-12-19

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