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Peptide aptamers in label-free protein detection: 2. Chemical optimization and detection of distinct protein isoforms.

Abstract:

The early detection and diagnosis of cancer lies central to successful treatment and improved patient outcome. Current techniques are limited by the nature of the biological receptor and the assays available. This paper reports the use of novel biological probes, peptide aptamers, in detecting cyclin-dependent protein kinases (CDKs) whose activity is important in proliferating and cancerous cells. We describe, specifically, the optimization of an orientated peptide aptamer surface and its uti...

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Publication status:
Published

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Publisher copy:
10.1021/ac802513n

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Inorganic Chemistry
Role:
Author
Journal:
Analytical chemistry More from this journal
Volume:
81
Issue:
9
Pages:
3314-3320
Publication date:
2009-05-01
DOI:
EISSN:
1520-6882
ISSN:
0003-2700
Language:
English
Keywords:
Pubs id:
pubs:34660
UUID:
uuid:1c57600d-8a9a-45f9-b218-851c69bf8a45
Local pid:
pubs:34660
Source identifiers:
34660
Deposit date:
2012-12-19

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