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Formyl peptide receptors and the regulation of ACTH secretion: targets for annexin A1, lipoxins, and bacterial peptides.

Abstract:

The N-formyl peptide receptors (FPRs) are a family of G-protein coupled receptors that respond to proinflammatory N-formylated bacterial peptides (e.g., formyl-Met-Leu-Phe, fMLF) and, thus, contribute to the host response to bacterial infection. Paradoxically, a growing body of evidence suggests that some members of this receptor family may also be targets for certain anti-inflammatory molecules, including annexin A1 (ANXA1), which is an important mediator of glucocorticoid (GC) action. To ex...

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Publication status:
Published

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Publisher copy:
10.1096/fj.06-7299com

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Journal:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume:
21
Issue:
4
Pages:
1037-1046
Publication date:
2007-04-01
DOI:
EISSN:
1530-6860
ISSN:
0892-6638
Source identifiers:
114715
Language:
English
Keywords:
Pubs id:
pubs:114715
UUID:
uuid:1c53e38d-96c1-4559-bfd3-3225e941eea4
Local pid:
pubs:114715
Deposit date:
2012-12-19

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