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Interleukin-4 induction of the CC chemokine TARC (CCL17) in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter

Abstract:

Background: Macrophages (Mθ) play a central role in the innate immune response and in the pathology of chronic inflammatory diseases. Macrophages treated with Th2-type cytokines such as Interleukin-4 (IL-4) and Interleukin-13 (IL-13) exhibit an altered phenotype and such alternatively activated macrophages are important in the pathology of diseases characterised by allergic inflammation including asthma and atopic dermatitis. The CC chemokine Thymus and Activation-Regulated Chemokine (TARC/CC...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1471-2199-7-45

Authors


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Institution:
University of Oxford
Department:
Sir William Dunn School of Pathology
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Institution:
University of California San Diego (UCSD)
Department:
Department of Medicine
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Institution:
University of California San Diego (UCSD)
Department:
Department of Medicine
More by this author
Institution:
University of California San Diego (UCSD)
Department:
Department of Medicine
More by this author
Institution:
University of California San Diego (UCSD)
Department:
Department of Medicine
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Funding agency for:
David R Greaves
Publisher:
BioMed Central
Journal:
BMC Molecular Biology Journal website
Volume:
7
Pages:
Article: 45
Publication date:
2006
DOI:
ISSN:
1471-2199
URN:
uuid:1c513f70-440d-4da2-9477-8650c79f2865
Local pid:
ora:2295
Language:
English
Keywords:
Subjects:

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