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In vitro evaluation of a 'stealth' adenoviral vector for targeted gene delivery to adult mammalian neurones.

Abstract:

BACKGROUND: Polymer coating of adenovirus type 5 (Ad5) particles produces a 'stealth' Ad5 (sAd5) that confers protection from immune recognition, blocks receptor-mediated uptake, and favours uptake into pinocytic cells. METHODS: In mixed cultures of primary adult rat dorsal root ganglion neurones (DRGN), rat C6 glioma cells, A9 non-Coxsackie and Ad Receptor (CAR)- and CAR-expressing fibroblasts, reporter gene expression after sAd5 pinocytotic uptake was monitored using the green fluorescent p...

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Publisher copy:
10.1002/jgm.1306

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Journal:
The journal of gene medicine
Volume:
11
Issue:
4
Pages:
335-344
Publication date:
2009-04-05
DOI:
EISSN:
1521-2254
ISSN:
1099-498X
URN:
uuid:1c508a2c-0008-4915-b5af-dd3b22d5a397
Source identifiers:
178785
Local pid:
pubs:178785

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