Intramembrane proteolysis controls diverse signalling pathways throughout evolution.

Journal article

Regulated intramembrane proteolysis (RIP) has recently emerged as a conserved mechanism for controlling many signalling pathways in both prokaryotes and eukaryotes. Although early examples were confined to the activation of membrane-tethered transcription factors in the cell receiving the signal, recent analysis indicates that RIP also regulates the emission of factors involved in intercellular communication.

Authors: Urban, S; Freeman, M

• Publication status: Published
• Journal: Current opinion in genetics and development
• Volume: 12
• Issue: 5
• Pages: 512-518
• Publication date: 2002-10-01
• DOI: 10.1016/s0959-437x(02)00334-9
• EISSN: 1879-0380
• ISSN: 0959-437X
• Language: English
• Keywords: Transcription Factors; Animals; Cysteine Endopeptidases; Intracellular Membranes; Proteasome Endopeptidase Complex; Cytoplasm; Cell Communication; Cell Nucleus; Humans; Active Transport, Cell Nucleus; Multienzyme Complexes; Signal Transduction; Evolution, Molecular; Endopeptidases