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Journal article

Hierarchically related lineage-restricted fates by multipotent hematopoietic stem cells

Abstract:

Rare multipotent haematopoietic stem cells (HSCs) in adult bone marrow with extensive self-renewal potential can efficiently replenish all myeloid and lymphoid blood cells1, securing long-term multilineage reconstitution after physiological and clinical challenges such as chemotherapy and haematopoietic transplantations2,3,4. HSC transplantation remains the only curative treatment for many haematological malignancies, but inefficient blood-lineage replenishment remains a major cause of morbid...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nature25455

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Clinical Laboratory Sciences
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Clinical Laboratory Sciences
Role:
Author
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Funding agency for:
Nerlov, C
Grant:
BB/M024350/1
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Funding agency for:
Nerlov, C
Grant:
BB/M024350/1
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Funding agency for:
Jacobsen, S
Grant:
MC_UU_12009/5
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Journal website
Volume:
554
Pages:
106-111
Publication date:
2018-01-03
Acceptance date:
2017-12-18
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Keywords:
Pubs id:
pubs:831864
UUID:
uuid:1c2ce389-22b3-4a87-a6b3-1f927aef80fa
Local pid:
pubs:831864
Deposit date:
2018-03-27

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