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Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP

Abstract:

Aurora kinases B and C (AURKB/AURKC) are activated by binding to the C-terminal domain of INCENP. Full activation requires phosphorylation of two serine residues of INCENP that are conserved through evolution, although the mechanism of this activation has not been explained. Here we present crystal structures of the fully active complex of AURKC bound to INCENP, consisting of phosphorylated, activated, AURKC and INCENP phosphorylated on its TSS motif, revealing the structural and biochemical ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-3231-2565
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Role:
Author
ORCID:
0000-0003-0113-2403
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Name:
Wellcome Trust
Grant:
106169/ZZ14/Z
Publisher:
Nature Research
Journal:
Nature Communications More from this journal
Volume:
10
Issue:
1
Article number:
3166
Publication date:
2019-07-18
Acceptance date:
2019-06-19
DOI:
EISSN:
2041-1723
Pmid:
31320618
Language:
English
Keywords:
Pubs id:
pubs:1035787
UUID:
uuid:1c15f7b4-98a4-47c1-89e9-a43aa0959716
Local pid:
pubs:1035787
Source identifiers:
1035787
Deposit date:
2019-10-07

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