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Normal hematopoietic progenitor subsets have distinct reactive oxygen species, BCL2 and cell-cycle profiles that are decoupled from maturation in acute myeloid leukemia

Abstract:

In acute myeloid leukemia (AML) quiescence and low oxidative state, linked to BCL2 mitochondrial regulation, endow leukemic stem cells (LSC) with treatment-resistance. LSC in CD34+ and more mature CD34- AML have heterogeneous immunophenotypes overlapping with normal stem/progenitor cells (SPC) but may be differentiated by functional markers. We therefore investigated the oxidative/reactive oxygen species (ROS) profile, its relationship with cell-cycle/BCL2 for normal SPC, and whether altered ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0163291

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Role:
Author
ORCID:
0000-0002-1433-8454
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Subgroup:
Clinical Trial Service Unit
Role:
Author
ORCID:
0000-0003-0166-0062
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Contributors

Role:
Editor
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
11
Issue:
9
Pages:
e0163291
Publication date:
2016-09-26
Acceptance date:
2016-09-05
DOI:
EISSN:
1932-6203
Pubs id:
pubs:648268
URN:
uri:1bff3b24-60ef-4e74-9587-dc39028f02e8
UUID:
uuid:1bff3b24-60ef-4e74-9587-dc39028f02e8
Local pid:
pubs:648268
Language:
English
Keywords:

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