Intestinal stromal cell types in health and inflammatory bowel disease uncovered by single-cell transcriptomics

Thesis

Colonic stromal cells provide critical structural support but also regulate immunity, tolerance and inflammatory responses in the mucosa. Substantial variability and plasticity of mucosal stromal cells has been reported but a paucity of distinct marker genes exist to identify distinct cell states. Here single-cell RNA-sequencing is used to document heterogeneity and subtype specific markers of individual colonic stromal cells in human and mouse.

Marker-free transcriptional clusterin...

Expand abstract

Authors: Kinchen, J

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: ulcerative colitis; single cell RNA sequencing
• Subjects: Inflammatory bowel diseases; Mesenchymal stem cells--Differentiation