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Thesis

Intestinal stromal cell types in health and inflammatory bowel disease uncovered by single-cell transcriptomics

Abstract:

Colonic stromal cells provide critical structural support but also regulate immunity, tolerance and inflammatory responses in the mucosa. Substantial variability and plasticity of mucosal stromal cells has been reported but a paucity of distinct marker genes exist to identify distinct cell states. Here single-cell RNA-sequencing is used to document heterogeneity and subtype specific markers of individual colonic stromal cells in human and mouse.

Marker-free transcriptional clusterin...

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Division:
MSD
Role:
Author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
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UUID:
uuid:1bf9d8f0-6d09-46f5-9d1e-3c9e0b826618
Deposit date:
2018-07-08

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