Journal article icon

Journal article

The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway

Abstract:

The helicase-associated endonuclease for fork-structured DNA (Hef) is an archaeabacterial protein that processes blocked replication forks. Here we have isolated the vertebrate Hef ortholog and investigated its molecular function. Disruption of this gene in chicken DT40 cells results in genomic instability and sensitivity to DNA cross-links. The similarity of this phenotype to that of cells lacking the Fanconi anemia-related (FA) tumor-suppressor genes led us to investigate whether Hef functi...

Expand abstract

Actions


Access Document


Publisher copy:
10.1038/nsmb981

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Journal:
Nature Structural and Molecular Biology More from this journal
Volume:
12
Issue:
9
Pages:
763-771
Publication date:
2005-09-01
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
Language:
English
Pubs id:
pubs:178367
UUID:
uuid:1bf4938f-abc7-44c9-8751-751e6cec9409
Local pid:
pubs:178367
Source identifiers:
178367
Deposit date:
2014-11-14

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP