Journal article
The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway
- Abstract:
-
The helicase-associated endonuclease for fork-structured DNA (Hef) is an archaeabacterial protein that processes blocked replication forks. Here we have isolated the vertebrate Hef ortholog and investigated its molecular function. Disruption of this gene in chicken DT40 cells results in genomic instability and sensitivity to DNA cross-links. The similarity of this phenotype to that of cells lacking the Fanconi anemia-related (FA) tumor-suppressor genes led us to investigate whether Hef functi...
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Bibliographic Details
- Journal:
- Nature Structural and Molecular Biology
- Volume:
- 12
- Issue:
- 9
- Pages:
- 763-771
- Publication date:
- 2005-09-01
- DOI:
- EISSN:
-
1545-9985
- ISSN:
-
1545-9993
Item Description
- Language:
- English
- Pubs id:
-
pubs:178367
- UUID:
-
uuid:1bf4938f-abc7-44c9-8751-751e6cec9409
- Local pid:
- pubs:178367
- Source identifiers:
-
178367
- Deposit date:
- 2014-11-14
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- Copyright date:
- 2005
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