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Chimeric Plasmodium falciparum parasites expressing Plasmodium vivax circumsporozoite protein fail to produce salivary gland sporozoites

Abstract:
Background Rodent malaria parasites where the gene encoding circumsporozoite protein (CSP) has been replaced with csp genes from the human malaria parasites, Plasmodium falciparum or Plasmodium vivax, are used as pre-clinical tools to evaluate CSP vaccines in vivo. These chimeric rodent parasites produce sporozoites in Anopheles stephensi mosquitoes that are capable of infecting rodent and human hepatocytes. The availability of chimeric P. falciparum parasites where the pfcsp... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12936-018-2431-1

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Role:
Author
ORCID:
0000-0001-6325-2828
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Wellcome Trust More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Malaria Journal Journal website
Volume:
17
Pages:
Article: 288
Publication date:
2018-08-09
Acceptance date:
2018-07-28
DOI:
ISSN:
1475-2875
Pubs id:
pubs:908372
URN:
uri:1bec65b1-81e8-4c07-a61a-76f8dfef1c08
UUID:
uuid:1bec65b1-81e8-4c07-a61a-76f8dfef1c08
Local pid:
pubs:908372

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