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Chimeric Plasmodium falciparum parasites expressing Plasmodium vivax circumsporozoite protein fail to produce salivary gland sporozoites

Abstract:
Background Rodent malaria parasites where the gene encoding circumsporozoite protein (CSP) has been replaced with csp genes from the human malaria parasites, Plasmodium falciparum or Plasmodium vivax, are used as pre-clinical tools to evaluate CSP vaccines in vivo. These chimeric rodent parasites produce sporozoites in Anopheles stephensi mosquitoes that are capable of infecting rodent and human hepatocytes. The availability of chimeric P. falciparum parasites where the pfcsp... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0001-6325-2828
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Name:
Colciencias
Grant:
568
Publisher:
BioMed Central
Journal:
Malaria Journal More from this journal
Volume:
17
Article number:
288
Publication date:
2018-08-09
Acceptance date:
2018-07-28
DOI:
ISSN:
1475-2875
Pmid:
30092798
Language:
English
Keywords:
Pubs id:
pubs:908372
UUID:
uuid:1bec65b1-81e8-4c07-a61a-76f8dfef1c08
Local pid:
pubs:908372
Source identifiers:
908372
Deposit date:
2018-08-30

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