Journal article
A three phase model to investigate the effects of dead material on the growth of avascular tumours
- Abstract:
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In vivo tumours are highly heterogeneous entities which often comprise intratumoural regions of hypoxia and widespread necrosis. In this paper, we develop a new three phase model of nutrient-limited, avascular tumour growth to investigate how dead material within the tumour may influence the tumour’s growth dynamics. We model the tumour as a mixture of tumour cells, dead cellular material and extracellular fluid. The model equations are derived using mass and momentum balances for each phase ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 2.7MB)
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- Publisher copy:
- 10.1051/mmnp/2019039
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Authors
Funding
Bibliographic Details
- Publisher:
- EDP Sciences Publisher's website
- Journal:
- Mathematical Modelling of Natural Phenomena Journal website
- Volume:
- 15
- Issue:
- 1
- Article number:
- 22
- Publication date:
- 2020-03-18
- Acceptance date:
- 2019-09-02
- DOI:
- EISSN:
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1760-6101
- ISSN:
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0973-5348
- Source identifiers:
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1053421
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:1053421
- UUID:
-
uuid:1be2438b-2403-4cca-a5e3-cb0717b985cb
- Local pid:
- pubs:1053421
- Deposit date:
- 2019-09-15
Terms of use
- Copyright holder:
- EDP Sciences.
- Copyright date:
- 2020
- Rights statement:
- © EDP Sciences, 2020
- Notes:
-
This is the publisher's version of the article. The final version is available online from EDP Sciences at: https://doi.org/10.1051/mmnp/2019039
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