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Paf1 has distinct roles in transcription elongation and differential transcript fate

Abstract:

RNA polymerase II (Pol2) movement through chromatin and the co-transcriptional processing and fate of nascent transcripts is coordinated by transcription elongation factors (TEFs) such as the polymerase-associated factor 1 (Paf1) but it is not known whether TEFs have gene-specific functions. Using strand-specific nucleotide resolution techniques, we show that levels of Paf1 on Pol2 vary between genes, are controlled dynamically by environmental factors via promoters, and reflect levels of pro...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
Queens College
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Fischl, H
Mellor, J
Grant:
097302/Z/11/Z
WT089156MA
WT089156MA
Strategic Award 091911
Publisher:
Cell Press
Journal:
Molecular Cell More from this journal
Volume:
65
Issue:
4
Pages:
685–698.e8
Publication date:
2017-02-09
Acceptance date:
2017-01-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
Keywords:
Pubs id:
pubs:668903
UUID:
uuid:1be05c2a-5527-49ec-9949-e82eb60c5e91
Local pid:
pubs:668903
Deposit date:
2017-01-11

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