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Use of FGF-21 as a biomarker of mitochondrial disease in clinical practice

Abstract:

Recent work has suggested that fibroblast growth factor-21 (FGF-21) is a useful biomarker of mitochondrial disease (MD). We routinely measured FGF-21 levels on patients who were investigated at our centre for MD and evaluated its diagnostic performance based on detailed genetic and other laboratory findings. Patients' FGF-21 results were assessed by the use of age-adjusted z-scores based on normalised FGF-21 values from a healthy population. One hundred and fifty five patients were investigat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3390/jcm6080080

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
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Funding agency for:
Poulton, J
Grant:
0948685/Z/10/Z
More from this funder
Funding agency for:
Poulton, J
Grant:
0948685/Z/10/Z
More from this funder
Funding agency for:
Poulton, J
Grant:
0948685/Z/10/Z
Publisher:
MDPI Publisher's website
Journal:
Journal of Clinical Medicine Journal website
Volume:
6
Issue:
8
Article number:
80
Publication date:
2017-08-21
Acceptance date:
2017-08-02
DOI:
ISSN:
2077-0383
Pmid:
28825656
Source identifiers:
724247
Language:
English
Keywords:
Pubs id:
pubs:724247
UUID:
uuid:1bd9ea68-0369-4a60-b2e0-29032e9e61b7
Local pid:
pubs:724247
Deposit date:
2017-11-25

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