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Neurotransmitter switching coupled to β-adrenergic signaling in sympathetic neurons in prehypertensive states

Abstract:

Single or combinatorial administration of β-blockers is a mainstay treatment strategy for conditions caused by sympathetic overactivity. Conventional wisdom suggests that the main beneficial effect of β-blockers includes resensitization and restoration of β1-adrenergic signaling pathways in the myocardium, improvements in cardiomyocyte contractility, and reversal of ventricular sensitization. However, emerging evidence indicates that another beneficial effect of β-blockers in disease may ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1161/hypertensionaha.118.10844

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Oxford college:
Merton College
Role:
Author
More from this funder
Name:
National Institutes of Health USA
Grant:
OT2OD023848
More from this funder
Name:
British Heart Foundation
Grant:
RG/17/14/33085
More from this funder
Name:
Wellcome Trust
Grant:
105409/Z/14/Z
Publisher:
American Heart Association
Journal:
Hypertension More from this journal
Volume:
71
Issue:
6
Pages:
1226-1238
Publication date:
2018-04-23
Acceptance date:
2018-03-26
DOI:
EISSN:
1524-4563
ISSN:
0194-911X
Pmid:
29686017
Language:
English
Keywords:
Pubs id:
pubs:844771
UUID:
uuid:1bcf4df7-eefd-463b-8a92-71e819943688
Local pid:
pubs:844771
Deposit date:
2018-05-04

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