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Neurotransmitter switching coupled to β-adrenergic signaling in sympathetic neurons in prehypertensive states

Abstract:

Single or combinatorial administration of β-blockers is a mainstay treatment strategy for conditions caused by sympathetic overactivity. Conventional wisdom suggests that the main beneficial effect of β-blockers includes resensitization and restoration of β1-adrenergic signaling pathways in the myocardium, improvements in cardiomyocyte contractility, and reversal of ventricular sensitization. However, emerging evidence indicates that another beneficial effect of β-blockers in disease may ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Version of record

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Publisher copy:
10.1161/hypertensionaha.118.10844

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Oxford college:
Merton College
Role:
Author
Publisher:
American Heart Association Publisher's website
Journal:
Hypertension Journal website
Volume:
71
Issue:
6
Pages:
1226-1238
Publication date:
2018-04-23
Acceptance date:
2018-03-26
DOI:
EISSN:
1524-4563
ISSN:
0194-911X
Pubs id:
pubs:844771
URN:
uri:1bcf4df7-eefd-463b-8a92-71e819943688
UUID:
uuid:1bcf4df7-eefd-463b-8a92-71e819943688
Local pid:
pubs:844771

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