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Inhibition of nigrostriatal dopamine release by striatal GABAA and GABAB receptors

Abstract:

Nigrostriatal dopamine (DA) is critical to action selection and learning. Axonal DA release is locally influenced by striatal neurotransmitters. Striatal neurons are comprised principally of GABAergic neurons, projection neurons and interneurons, while a minority are cholinergic interneurons (ChIs). ChIs strongly gate striatal DA release via identified nicotinic receptors (nAChRs) on DA axons. Striatal GABA is thought to modulate DA, but GABA receptors have not been documented conclusively ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1523/JNEUROSCI.2028-18.2018

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Oxford college:
St Edmund Hall
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Oxford college:
Christ Church College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Oxford college:
Christ Church College
Role:
Author
ORCID:
0000-0001-9677-2256
Biotechnology and Biological Sciences Research Council More from this funder
Publisher:
Society for Neuroscience Publisher's website
Journal:
Journal of Neuroscience Journal website
Volume:
39
Issue:
6
Pages:
1058-1065
Publication date:
2018-12-12
Acceptance date:
2018-11-15
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
Pubs id:
pubs:943527
URN:
uri:1bccfab0-c59a-4632-a757-3fdc14e9b7df
UUID:
uuid:1bccfab0-c59a-4632-a757-3fdc14e9b7df
Local pid:
pubs:943527

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