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The role of the unfolded protein response in dengue virus pathogenesis

Abstract:

Symptomatic dengue virus (DENV) infections range from mild fever to severe haemorrhagic disease and death. Host-viral interactions play a significant role in deciding the fate of the infection. The unfolded protein response (UPR) is a pro-survival cellular reaction induced in response to DENV mediated ER stress. The UPR has complex interactions with the cellular autophagy machinery, apoptosis and innate immunity. DENV has evolved to manipulate the UPR to facilitate its replication and to evad...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1111/cmi.12734

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Department:
Oxford, MSD, Biochemistry
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Department:
Oxford, MSD, Biochemistry
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Department:
Merton College
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Funding agency for:
Zitzmann, N
Publisher:
Wiley Publisher's website
Journal:
Cellular Microbiology Journal website
Volume:
19
Issue:
5
Pages:
e12734
Publication date:
2017-03-05
Acceptance date:
2017-02-15
DOI:
EISSN:
1462-5822
ISSN:
1462-5814
Pubs id:
pubs:680085
URN:
uri:1bb812fb-8491-4eed-bc10-9d5c6ba3ff17
UUID:
uuid:1bb812fb-8491-4eed-bc10-9d5c6ba3ff17
Local pid:
pubs:680085
Keywords:

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