Journal article icon

Journal article

The role of the unfolded protein response in dengue virus pathogenesis

Abstract:

Symptomatic dengue virus (DENV) infections range from mild fever to severe haemorrhagic disease and death. Host-viral interactions play a significant role in deciding the fate of the infection. The unfolded protein response (UPR) is a pro-survival cellular reaction induced in response to DENV mediated ER stress. The UPR has complex interactions with the cellular autophagy machinery, apoptosis and innate immunity. DENV has evolved to manipulate the UPR to facilitate its replication and to evad...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1111/cmi.12734

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
Merton College
Role:
Author
More from this funder
Funding agency for:
Zitzmann, N
Publisher:
Wiley Publisher's website
Journal:
Cellular Microbiology Journal website
Volume:
19
Issue:
5
Pages:
e12734
Publication date:
2017-03-01
Acceptance date:
2017-02-15
DOI:
EISSN:
1462-5822
ISSN:
1462-5814
Source identifiers:
680085
Keywords:
Pubs id:
pubs:680085
UUID:
uuid:1bb812fb-8491-4eed-bc10-9d5c6ba3ff17
Local pid:
pubs:680085
Deposit date:
2017-02-15

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP