Journal article
ADGRL4/ELTD1 is a highly conserved angiogenesis-associated orphan adhesion GPCR that emerged with the first vertebrates and comprises 3 evolutionary variants
- Abstract:
-
Background: Our laboratory identified ADGRL4/ELTD1, an orphan GPCR belonging to the adhesion GPCR (aGPCR) family, as a novel regulator of angiogenesis and a potential anti-cancer therapeutic target. Little is known about how ADGRL4/ELTD1 (and aGPCRs in general) function, a problem compounded by a lack of known ligands or means of activation. With this in mind, we turned to computational evolutionary biology with the aim of better understanding ADGRL4/ELTD1.Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Bibliographic Details
- Publisher:
- BioMed Central Publisher's website
- Journal:
- BMC Evolutionary Biology Journal website
- Volume:
- 19
- Issue:
- 2019
- Article number:
- 143
- Publication date:
- 2019-07-12
- Acceptance date:
- 2019-05-27
- DOI:
- EISSN:
-
1471-2148
- Pmid:
-
31299890
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1036742
- UUID:
-
uuid:1baf1174-b578-453c-ad52-78ef318c4207
- Local pid:
- pubs:1036742
- Source identifiers:
-
1036742
- Deposit date:
- 2019-08-14
Terms of use
- Copyright holder:
- Favara, Banham and Harris
- Copyright date:
- 2019
- Rights statement:
- © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License
- Licence:
- CC Attribution (CC BY)
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