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A quantitative evaluation of MIRU-VNTR typing against whole-genome sequencing for identifying Mycobacterium tuberculosis transmission: a prospective observational cohort study

Abstract:

Mycobacterial Interspersed Repetitive Unit-Variable Number Tandem Repeat (MIRU-VNTR) typing is widely used in high-income countries to determine Mycobacterium tuberculosis relatedness. Whole-genome sequencing (WGS) is known to deliver greater specificity, but no quantitative prospective comparison has yet been undertaken.We studied isolates from the English Midlands, sampled consecutively between 1 January 2012 and 31 December 2015. In addition to routinely performed MIRU-VNTR typing, DNA was...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.ebiom.2018.07.019

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
Oxford college:
Harris Manchester College
Davidson, JA More by this author
Grace Smith, E More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Clinical Laboratory Sciences
ORCID:
0000-0002-0590-2850
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Publisher:
Elsevier Publisher's website
Journal:
EBioMedicine Journal website
Volume:
34
Pages:
122-130
Publication date:
2018-08-01
Acceptance date:
2018-07-15
DOI:
ISSN:
2352-3964
Pubs id:
pubs:894261
URN:
uri:1ba282cd-7399-411d-902a-2d823cf6a62c
UUID:
uuid:1ba282cd-7399-411d-902a-2d823cf6a62c
Local pid:
pubs:894261

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