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Journal article

Population pharmacokinetic properties of antituberculosis drugs in Vietnamese children with tuberculous meningitis

Abstract:

Optimal dosing of children with tuberculous meningitis (TBM) remains uncertain and is currently based on the treatment of pulmonary tuberculosis in adults. This study aimed to investigate the population pharmacokinetics of isoniazid, rifampin, pyrazinamide, and ethambutol in Vietnamese children with TBM, to propose optimal dosing in these patients, and to determine the relationship between drug exposure and treatment outcome. A total of 100 Vietnamese children with TBM were treated with an 8-...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/aac.00487-20

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial Agents and Chemotherapy Journal website
Volume:
65
Issue:
1
Article number:
e00487-20
Place of publication:
United States
Publication date:
2020-12-16
Acceptance date:
2020-10-13
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Pmid:
33139294
Language:
English
Keywords:
Pubs id:
1141247
Local pid:
pubs:1141247
Deposit date:
2021-01-20

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