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Intravenous magnesium sulfate for the management of severe hand, foot, and mouth disease with autonomic nervous system dysregulation in Vietnamese children: study protocol for a randomized controlled trial

Abstract:

Over the last 15 years, hand, foot, and mouth disease (HFMD) has emerged as a major public health burden across the Asia-Pacific region. A small proportion of HFMD patients, typically those infected with enterovirus 71 (EV71), develop brainstem encephalitis with autonomic nervous system (ANS) dysregulation and may progress rapidly to cardiopulmonary failure and death. Although milrinone has been reported to control hypertension and support myocardial function in two small studies, in practice...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s13063-016-1215-6

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Wellcome Trust More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Trials Journal website
Volume:
17
Issue:
98
Publication date:
2016-02-19
Acceptance date:
2016-02-05
DOI:
ISSN:
1745-6215
Pmid:
26896318
Language:
English
Keywords:
Pubs id:
pubs:606067
UUID:
uuid:1b7c6f6c-9a12-4384-9c9f-5036e23cc552
Local pid:
pubs:606067
Deposit date:
2016-11-01

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