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Journal article

Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error

Abstract:

Refractive errors, including myopia, are the most frequent eye disorders worldwide and an increasingly common cause of blindness. This genome-wide association meta-analysis in 160,420 participants and replication in 95,505 participants increased the number of established independent signals from 37 to 161 and showed high genetic correlation between Europeans and Asians (>0.78). Expression experiments and comprehensive in silico analyses identified retinal cell physiology and light processi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41588-018-0127-7

Authors


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Role:
Author
ORCID:
0000-0003-0356-9684
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Role:
Author
ORCID:
0000-0001-5752-2510
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Name:
National Eye Institute
Grant:
R01EY020483
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Name:
Netherlands Organisation for Scientific Research
Grant:
91815655
More from this funder
Name:
European Research Council
Grant:
648268
Publisher:
Springer Nature
Journal:
Nature Genetics More from this journal
Volume:
50
Issue:
6
Pages:
834-848
Publication date:
2018-05-28
Acceptance date:
2018-03-26
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Pmid:
29808027
Language:
English
Keywords:
Pubs id:
pubs:856374
UUID:
uuid:1b7bed67-172e-4066-a18b-8a4af318836b
Local pid:
pubs:856374
Source identifiers:
856374
Deposit date:
2018-10-23

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