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Journal article

Orchestrating the nucleases involved in DNA interstrand cross-link (ICL) repair.

Abstract:

DNA interstrand cross-links (ICLs) pose a significant threat to genomic and cellular integrity by blocking essential cellular processes, including replication and transcription. In mammalian cells, much ICL repair occurs in association with DNA replication during S phase, following the stalling of a replication fork at the block caused by an ICL lesion. Here, we review recent work showing that the XPF-ERCC1 endonuclease and the hSNM1A exonuclease act in the same pathway, together with SLX4, t...

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Publication status:
Published

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Publisher copy:
10.4161/cc.10.23.18385

Authors


Sengerová, B More by this author
McHugh, PJ More by this author
Journal:
Cell cycle (Georgetown, Tex.)
Volume:
10
Issue:
23
Pages:
3999-4008
Publication date:
2011-12-05
DOI:
EISSN:
1551-4005
ISSN:
1538-4101
URN:
uuid:1b7bad9c-6011-45b2-bef1-c056b39f81fd
Source identifiers:
221594
Local pid:
pubs:221594

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