- Abstract:
-
DNA interstrand cross-links (ICLs) pose a significant threat to genomic and cellular integrity by blocking essential cellular processes, including replication and transcription. In mammalian cells, much ICL repair occurs in association with DNA replication during S phase, following the stalling of a replication fork at the block caused by an ICL lesion. Here, we review recent work showing that the XPF-ERCC1 endonuclease and the hSNM1A exonuclease act in the same pathway, together with SLX4, t...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.4161/cc.10.23.18385
-
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- Journal:
- Cell cycle (Georgetown, Tex.)
- Volume:
- 10
- Issue:
- 23
- Pages:
- 3999-4008
- Publication date:
- 2011-12-05
- DOI:
- EISSN:
-
1551-4005
- ISSN:
-
1538-4101
- URN:
-
uuid:1b7bad9c-6011-45b2-bef1-c056b39f81fd
- Source identifiers:
-
221594
- Local pid:
- pubs:221594
- Copyright date:
- 2011
Journal article
Orchestrating the nucleases involved in DNA interstrand cross-link (ICL) repair.
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