Dataset
LIM domain kinase 1 (LIMK1), human kinase domain; A Target Enabling Package
- Documentation:
-
A description of the materials and methods is included within the TEP datasheet. Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BMP receptor BMPR2 and its non-canonical signalling via the kinase LIMK1. LIMK1 performs inhibitory phosphorylation on cofilin proteins blocking their actin-severing activity. Excessive BMPR2-LIMK1 activation was associated with dendritic spine and behavioural defects in animal models that could be rescued by BMPR2 ...
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- Version:
- 1
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Authors/Creators
Contributors
+ Salah, E
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Researcher
+ Knapp, S
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Researcher
+ Beltrami, A
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Researcher
+ Chaikuad, A
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Researcher
+ Hanke, T
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Researcher
Funding
Bibliographic Details
- Publisher:
- University of Oxford
- Publication date:
- 2018
- Version number:
- 1
- DOI:
Item Description
- Keywords:
- Subjects:
- UUID:
-
uuid:1b3f34b2-5c3e-40ba-8b76-f6e687fd71d4
- Deposit date:
- 2018-04-04
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- Copyright date:
- 2018
- Licence:
- ORA Terms and conditions
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