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Use of proteomics to discover novel markers of cardiac allograft rejection.

Abstract:

Endomyocardial biopsy remains the most reliable method of detecting rejection following cardiac transplantation. Despite numerous attempts to detect rejection using a blood assay, none have proved reliable enough to replace the biopsy. Here, we have investigated the hypothesis that proteomics has the potential to reveal many molecules which are upregulated in the heart during rejection, some of which may serve as novel blood markers of rejection. Initially, sequential cardiac biopsies (33 in ...

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Publication status:
Published

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Publisher copy:
10.1021/pr034059r

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Journal:
Journal of proteome research
Volume:
3
Issue:
2
Pages:
282-288
Publication date:
2004-01-01
DOI:
EISSN:
1535-3907
ISSN:
1535-3893
Source identifiers:
230057

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