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Development of an algorithm to discriminate between plasmid- and chromosomal-mediated AmpC β-lactamase production in Escherichia coli by elaborate phenotypic and genotypic characterization

Abstract:

Objectives AmpC-β-lactamase production is an under-recognized antibiotic resistance mechanism that renders Gram-negative bacteria resistant to common β-lactam antibiotics, similar to the well-known ESBLs. For infection control purposes, it is important to be able to discriminate between plasmid-mediated AmpC (pAmpC) production and chromosomal-mediated AmpC (cAmpC) hyperproduction in Gram-negative bacteria as pAmpC requires isolation precautions to minimize the risk of horizontal gene transmis...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/jac/dkz362

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Role:
Author
ORCID:
0000-0003-0443-6250
More by this author
Role:
Author
ORCID:
0000-0002-6092-5983
Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Antimicrobial Chemotherapy Journal website
Volume:
74
Issue:
12
Pages:
3481-3488
Publication date:
2019-08-25
Acceptance date:
2019-07-19
DOI:
EISSN:
1460-2091
ISSN:
0305-7453
Pmid:
31504559

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