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Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload

Abstract:

Iron-related disorders are among the most prevalent diseases worldwide. Systemic iron homeostasis requires hepcidin, a liver-derived hormone that controls iron mobilization through its molecular target ferroportin (FPN), the only known mammalian iron exporter. This pathway is perturbed in diseases that cause iron overload. Additionally, intestinal HIF-2α is essential for the local absorptive response to systemic iron deficiency and iron overload. Our data demonstrate a hetero-tissue crosstalk...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1172/JCI122359

Authors


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Name:
NIEHS NIH HHS
Grant:
R01 ES028802
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Name:
NCI NIH HHS
Grant:
P50 CA130810
R01 CA148828
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Name:
NIDDK NIH HHS
Grant:
F31 DK116555
K99 DK110537
R01 DK095201
R01 DK107309
R01 DK107583
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Name:
Kidney Research UK
Grant:
RP_020_20160303
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Name:
British Heart Foundation
Grant:
FS/12/63/29895
Publisher:
American Society for Clinical Investigation
Journal:
Journal of Clinical Investigation More from this journal
Volume:
129
Issue:
1
Pages:
336-348
Publication date:
2018-10-23
Acceptance date:
2018-10-16
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Pmid:
30352047
Language:
English
Keywords:
Pubs id:
pubs:952864
UUID:
uuid:1b2f44fd-b66f-4572-9881-3d248326a274
Local pid:
pubs:952864
Source identifiers:
952864
Deposit date:
2019-05-21

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